In an era where cyber threats are increasingly sophisticated, endpoint protection has become a cornerstone of enterprise cybersecurity. As businesses rely on distributed networks, cloud environments, and remote workforces, securing endpoints-devices like laptops, desktops, and mobile devices-is critical to preventing breaches. This article highlights the top 14 endpoint protection companies in the USA for 2025, showcasing leaders in AI-driven threat detection, response, and prevention. These firms, all based in the USA, offer innovative solutions to protect organizations across industries, from finance to healthcare, ensuring robust security against ransomware, phishing, and advanced persistent threats.
1. A-Listware
At A-Listware, we redefine endpoint protection by integrating cutting-edge cloud infrastructure solutions with advanced cybersecurity practices. Our expertise in designing and managing scalable cloud environments ensures that businesses can secure their endpoints while maintaining operational efficiency. We provide comprehensive support for hybrid and cloud-native architectures, enabling seamless integration of endpoint protection tools that safeguard devices against evolving threats with minimal disruption.
Our services combine AI-driven monitoring and automation to deliver real-time threat detection and response, tailored to each client’s unique needs. By leveraging DevOps methodologies and continuous system oversight, we ensure that endpoint security aligns with broader IT infrastructure goals, protecting e-commerce platforms, engineering solutions, and enterprise applications. A-Listware is committed to setting the standard for secure, adaptable endpoint protection in the digital age.
Key Highlights
- Leadership in cloud infrastructure for endpoint security
- Expertise in hybrid and cloud-native system integration
- Continuous monitoring for real-time threat detection
- Tailored solutions for diverse industries
- Advanced automation for operational efficiency
- Comprehensive support for secure cloud migrations
Key Services
- Cloud infrastructure design for endpoint protection
- Real-time system performance and threat monitoring
- Hybrid cloud security management
- Disaster recovery and threat mitigation planning
- DevOps-driven automation for endpoint security
Contact Information
- Website: a-listware.com
- Address: North Bergen, NJ 07047, USA
- Phone Number: +1 (888) 337 93 73
- Email: info@a-listware.com
- Facebook: facebook.com/alistware
- LinkedIn: linkedin.com/company/a-listware/mycompany
2. CrowdStrike
CrowdStrike’s Falcon® platform is a leader in AI-native endpoint protection, delivering real-time threat detection and response across endpoints, cloud, and identity environments. By leveraging advanced AI and behavioral analytics, CrowdStrike stops breaches, ransomware, and insider threats, serving industries like finance, healthcare, and government with scalable, cloud-delivered solutions.
The company’s managed detection and response (MDR) services, combined with next-generation SIEM and threat hunting, empower Security Operations Centers (SOCs) to stay ahead of adversaries. CrowdStrike’s unified approach ensures seamless integration and rapid deployment, making it a trusted choice for enterprises seeking comprehensive endpoint security.
Key Highlights
- AI-native Falcon® platform for endpoint protection
- Recognized leader in endpoint and cloud security
- Real-time threat detection and response
- Scalable solutions for diverse industries
- Next-generation SIEM and threat hunting capabilities
- Global customer base with rapid deployment
Key Services
- Endpoint protection (EPP, EDR)
- Cloud security
- Identity protection
- Managed detection and response (MDR)
- Ransomware protection
- Threat hunting
Contact Information
- Website: crowdstrike.com
- Email: info@crowdstrike.com
- Phone: 1.888.512.8906
- Address: 140 Mathilda Place Sunnyvale, CA 94086
- Facebook: facebook.com/CrowdStrike
- LinkedIn: linkedin.com/company/crowdstrike
- X (Twitter): x.com/CrowdStrike
- Instagram: instagram.com/crowdstrike
- YouTube: youtube.com/@CrowdStrike
3. SentinelOne
SentinelOne’s Singularity platform delivers AI-powered endpoint protection, integrating detection, response, and risk management across endpoints, cloud workloads, and identity resources. Its Purple AI tool accelerates threat hunting and response, providing enterprises with actionable insights through a centralized Singularity Data Lake.
The platform’s autonomous capabilities ensure real-time protection against ransomware and zero-day threats, with 24/7 managed services enhancing SOC efficiency. SentinelOne’s focus on extended detection and response (XDR) makes it a top choice for organizations seeking unified, scalable endpoint security.
Key Highlights
- AI-driven Singularity platform for endpoint security
- Centralized Singularity Data Lake for actionable insights
- Purple AI for accelerated threat detection
- Managed security services
- Comprehensive XDR capabilities
- Protection across endpoints, cloud, and identities
Key Services
- Endpoint protection (EPP, EDR, XDR)
- Cloud workload protection
- Identity risk reduction
- AI-powered threat detection
- Security log analytics
- Managed threat hunting
Contact Information
- Website: sentinelone.com
- Email: sales@sentinelone.com
- Phone: +1-855-868-3733
- Address: 444 Castro Street, Suite 400, Mountain View, CA 94041
- Facebook: facebook.com/SentinelOne
- LinkedIn: linkedin.com/company/sentinelone
- X (Twitter): x.com/SentinelOne
4. Trellix
Trellix, formed from the merger of McAfee Enterprise and FireEye, offers a GenAI-powered platform for endpoint security, leveraging AI and automation to detect and respond to threats across hybrid, cloud, and on-premises environments. Its Trellix Wise solution enhances threat investigations and prioritization, ensuring rapid response to advanced attacks.
The platform provides unified security for endpoints, email, networks, and cloud, with a focus on operational intelligence and resilience. Trellix’s AI-driven approach streamlines security operations, making it ideal for enterprises seeking comprehensive endpoint protection.
Key Highlights
- GenAI-powered platform for endpoint security
- Unified security across hybrid and cloud environments
- Trellix Wise for guided threat investigations
- Formed from McAfee and FireEye merger
- Focus on automation and analytics
- Global enterprise customer base
Key Services
- Endpoint security
- Network security
- Data security
- Email security
- Cloud security
- Advanced threat detection and response
Contact Information
- Website: trellix.com
- Email: peopleservices@trellix.com
- LinkedIn: linkedin.com/company/trellixsecurity
- Twitter: x.com/Trellix
- YouTube: youtube.com/trellixsecurity
5. Fortinet
Fortinet’s Fortinet Security Fabric provides AI-driven endpoint protection integrated with secure networking solutions, powered by its FortiOS operating system. The platform offers endpoint detection and response (EDR), zero-trust network access (ZTNA), and next-generation firewalls, protecting organizations worldwide.
Fortinet’s AI systems process vast threat data daily, enabling real-time threat detection and automated response. Its unified approach ensures seamless security across distributed networks, making it a leader in enterprise-grade endpoint protection.
Key Highlights
- AI-driven Fortinet Security Fabric for endpoint security
- Serves organizations globally
- Extensive patent portfolio
- Powered by FortiOS operating system
- Real-time threat detection and response
- Unified secure networking and endpoint protection
Key Services
- Endpoint protection (EPP, EDR)
- Secure networking (NGFW, SD-WAN, ZTNA)
- AI-powered threat detection
- Security information and event management (SIEM)
- Cloud security (SASE, cloud firewalls)
- Zero-trust network access
Contact Information
- Website: fortinet.com
- Email: cs@fortinet.com
- Phone: +1-408-235-7700
- Address: 909 Kifer Road, Sunnyvale, CA 94086 USA
- Facebook: facebook.com/fortinet
- LinkedIn: linkedin.com/company/fortinet
- Twitter: x.com/Fortinet
- Instagram: instagram.com/fortinet
- YouTube: youtube.com/@fortinet
6. Check Point
Check Point’s Infinity Platform delivers AI-powered endpoint protection through its Harmony suite, integrating threat intelligence to secure networks, clouds, and workspaces. Achieving a high detection rate in MITRE ATT&CK Evaluations, Check Point excels in preventing phishing, malware, and advanced threats.
The company’s prevention-first approach, combined with managed security services and security consulting, ensures enterprise-grade protection. Check Point’s unified platform simplifies security operations, making it a top choice for organizations seeking robust endpoint solutions.
Key Highlights
- AI-powered Infinity Platform for endpoint security
- High detection rate in MITRE ATT&CK Evaluations
- Unified solutions for network, cloud, and endpoint
- Prevention-first security approach
- Global enterprise customer base
- Comprehensive security consulting services
Key Services
- Endpoint and workspace security (Harmony)
- Network security (Quantum)
- Cloud security (CloudGuard)
- AI-powered threat intelligence
- Managed security services
- Phishing and malware prevention
Contact Information
- Website: checkpoint.com
- Email: lizwu@checkpoint.com
- Phone: +1-800-429-4391
- Address: 100 Oracle Parkway, Suite 800, Redwood City, CA 94065
- Facebook: facebook.com/checkpointsoftware
- LinkedIn: linkedin.com/company/check-point-software-technologies
- X (Twitter): x.com/checkpointsw
- YouTube: youtube.com/CPGlobal
7. Vectra AI
Vectra AI’s Attack Signal Intelligence platform delivers AI-driven extended detection and response (XDR) for endpoints, networks, clouds, and identities. By detecting hybrid attacks early, Vectra minimizes damage through real-time response, serving industries like banking, healthcare, and government.
With numerous patents, Vectra’s platform reduces blind spots and prioritizes high-fidelity alerts, enhancing security operations. Its managed detection and response (MXDR) services ensure rapid remediation, making it a key player in endpoint protection.
Key Highlights
- AI-driven XDR for endpoint protection
- Extensive patents in AI threat detection
- Real-time detection of hybrid attacks
- Serves finance, healthcare, and government sectors
- Managed detection and response (MXDR) services
- Focus on reducing blind spots
Key Services
- Extended detection and response (XDR)
- Endpoint security
- Network security
- Cloud security
- Identity security
- Ransomware detection
Contact Information
- Website: vectra.ai
- Email: support@vectra.ai
- Phone: +1 408-326-2020
- Address: 550 S. Winchester Boulevard, Suite 200, San Jose, CA 95128
- Facebook: facebook.com/VectraAI
- LinkedIn: linkedin.com/company/vectra_ai
- X (Twitter): x.com/vectra_ai
- Instagram: instagram.com/vectra_ai
- YouTube: youtube.com/@VectraAI
8. Deep Instinct
Deep Instinct’s Data Security X (DSX) platform uses deep learning and generative AI to prevent zero-day threats with high accuracy in minimal time. Protecting endpoints, cloud, and storage systems, it ensures real-time security across enterprise environments.
The platform’s purpose-built deep learning framework explains unknown threats, integrating seamlessly with platforms like AWS and Dell. Deep Instinct’s focus on speed and accuracy makes it a leader in proactive endpoint protection.
Key Highlights
- Deep learning for zero-day threat prevention
- High accuracy with minimal false positives
- Real-time protection in minimal time
- Covers endpoints, cloud, and storage
- Seamless integration with AWS, NetApp, Dell
- Generative AI for threat explanation
Key Services
- Zero-day data security
- Deep learning-based cybersecurity
- Real-time threat prevention
- Generative AI for threat analysis
- Cloud and endpoint protection
- Storage system security
Contact Information
- Website: deepinstinct.com
- Email: info@deepinstinct.com
- Phone: +1 347-534-1314
- Address: 888 Seventh Avenue, 5th floor, New York, NY, 10106, USA
- Facebook: facebook.com/DeepInstinctInc
- LinkedIn: linkedin.com/company/deep-instinct
- X (Twitter): x.com/DeepInstinctSec
- YouTube: youtube.com/@deepinstinct
9. Balbix
Balbix provides an AI-driven cybersecurity platform focused on endpoint risk management, offering visibility into attack surfaces and actionable insights for CISOs. By quantifying cyber risk and prioritizing vulnerabilities, Balbix helps enterprises in finance, healthcare, and manufacturing reduce threats effectively.
The platform automates asset management, vulnerability assessment, and compliance, integrating with existing security tools to streamline operations. Balbix’s focus on business impact analysis ensures endpoint protection aligns with organizational priorities.
Key Highlights
- AI-driven platform for endpoint risk management
- Quantifies cyber risk for prioritized action
- Serves finance, healthcare, and manufacturing
- Automates asset and vulnerability management
- Integrates with existing security infrastructure
- Focus on business impact analysis
Key Services
- Cyber risk quantification
- Cyber asset attack surface management
- Risk-based vulnerability management
- Application security risk management
- Software bill-of-materials management
- Endpoint risk assessment
Contact Information
- Website: balbix.com
- Email: privacyteam@balbix.com
- Phone: +1 866 936 3180
- Address: 3031 Tisch Way, Ste. 800, San Jose, CA 95128
- LinkedIn: linkedin.com/company/balbix
10. IronNet
IronNet’s Collective Defense platform provides AI-driven endpoint protection through network detection and response (NDR), leveraging behavioral analytics and crowdsourced threat intelligence. Its IronRadar tool offers proactive threat detection, protecting critical industries like healthcare and energy.
With 24/7 NDR services and automated cyber defense via IronDome, IronNet enhances SOC capabilities. Its collaborative approach ensures real-time defense against sophisticated endpoint threats.
Key Highlights
- AI-driven NDR for endpoint protection
- Collective Defense platform for real-time collaboration
- Overwatch NDR services
- IronRadar for proactive threat intelligence
- Protects healthcare, energy, and defense sectors
- Automated cyber defense with IronDome
Key Services
- Network detection and response (NDR)
- IronRadar threat intelligence feed
- Collective Defense platform
- Overwatch services (24/7 NDR)
- IronDome automated cyber defense
- Endpoint threat detection
Contact Information
- Website: ironnet.com
- Email: privacy@ironnetcybersecurity.com
- LinkedIn: linkedin.com/company/ironnet
- X (Twitter): x.com/IronNet
11. BROADCOM
VMware Carbon Black by Broadcom offers cloud-native endpoint protection and EDR, delivering real-time threat detection and response for enterprises. Its platform leverages behavioral analytics to stop advanced threats, including ransomware and fileless attacks, with minimal system impact.
Integrated with VMware’s broader security portfolio, Broadcom provides scalable solutions for SOCs, ensuring rapid incident response and compliance. Its cloud-delivered architecture enhances endpoint security for distributed workforces.
Key Highlights
- Cloud-native endpoint protection and EDR
- Behavioral analytics for advanced threat detection
- Scalable solutions for enterprise SOCs
- Minimal system impact for efficient performance
- Integrated with VMware security portfolio
- Rapid incident response and compliance
Key Services
- Endpoint protection
- Endpoint detection and response (EDR)
- Threat hunting
- Incident response
- Ransomware protection
- Compliance management
Contact Information
- Website: broadcom.com
- Phone: +1-617-393-7400
- Address: 3401 Hillview Ave, Palo Alto, CA 94304, USA
- Facebook: facebook.com/CarbonBlackInc
- LinkedIn: linkedin.com/company/broadcom
- X (Twitter): x.com/Broadcom
- YouTube: youtube.com/user/BroadcomCorporation
12. Bitdefender
Bitdefender’s GravityZone platform delivers multilayered endpoint protection and response, using AI and machine learning to prevent threats with low system impact. It offers EDR, risk analytics, and patch management, securing enterprises across industries like retail and education.
The platform’s centralized management and real-time visibility ensure rapid response to endpoint threats. Bitdefender’s focus on performance and accuracy makes it a reliable choice for comprehensive endpoint security.
Key Highlights
- GravityZone platform for endpoint protection
- AI and machine learning for threat prevention
- Low system impact for optimal performance
- Centralized management for real-time visibility
- Serves retail, education, and other industries
- Comprehensive EDR and risk analytics
Key Services
- Endpoint protection
- Endpoint detection and response (EDR)
- Risk analytics
- Patch management
- Threat prevention
- Centralized security management
Contact Information
- Website: bitdefender.com
- Address: 3945 Freedom Circle, Suite 500, Santa Clara, CA, 95054
- Email: office@bitdefender.com
- Facebook: facebook.com/bitdefender
- LinkedIn: linkedin.com/company/bitdefender
- X (Twitter): x.com/Bitdefender
- Instagram: instagram.com/bitdefender_official
- YouTube: youtube.com/@Bitdefender
13. Malwarebytes
Malwarebytes’ ThreatDown Endpoint Protection platform provides lightweight, cloud-native endpoint security with behavioral analysis and zero-day protection. It safeguards enterprises against malware, ransomware, and malicious URLs, with a focus on ease of setup and minimal resource strain.
Managed through the Nebula cloud portal, Malwarebytes offers application hardening and web protection, making it a cost-effective solution for businesses seeking proactive endpoint security.
Key Highlights
- Lightweight, cloud-native endpoint protection
- Behavioral analysis for zero-day threats
- Application hardening to reduce attack surfaces
- Web protection against malicious URLs
- Cost-effective and easy to deploy
- Minimal resource impact
Key Services
- Endpoint protection
- Zero-day threat detection
- Behavioral analysis
- Web protection
- Application hardening
- Cloud-based management
Contact Information
- Website: malwarebytes.com
- Address: One Albert Quay 2nd Floor Cork T12 X8N6 Ireland
- Email: legal@malwarebytes.com
- X (Twitter): x.com/malwarebytes
- Facebook: facebook.com/Malwarebytes
- LinkedIn: linkedin.com/company/malwarebytes
- YouTube: youtube.com/user/Malwarebytes
- Instagram: instagram.com/malwarebytesofficial
14. Microsoft
Microsoft Defender for Endpoint provides integrated endpoint protection for Windows, macOS, iOS, and Android devices, leveraging real-time analytics and automated response. Recognized as a leader in endpoint security, it protects against malware, phishing, and ransomware with seamless integration into Microsoft 365.
Its threat and vulnerability management prioritizes risks, ensuring rapid remediation. Microsoft’s extensive customer base and cloud-based architecture make it a top choice for enterprises seeking unified endpoint security.
Key Highlights
- Integrated endpoint protection across platforms
- Real-time analytics and automated response
- Recognized leader in endpoint security
- Seamless integration with Microsoft 365
- Threat and vulnerability management
- Extensive enterprise customer base
Key Services
- Endpoint protection
- Threat and vulnerability management
- Automated threat response
- Real-time analytics
- Cross-platform security
- Phishing and ransomware protection
Contact Information
- Website: microsoft.com
- Address: One Microsoft Way, Redmond, WA 98052, USA
- Facebook: facebook.com/Microsoft
- LinkedIn: linkedin.com/company/microsoft
- X (Twitter): x.com/Microsoft
Conclusion
The top 14 endpoint protection companies in the USA for 2025 are driving cybersecurity innovation, leveraging AI and automation to safeguard enterprises from evolving threats. From A-Listware’s cloud-integrated solutions to Microsoft’s cross-platform protection, these firms offer robust tools to secure endpoints across diverse industries. Their focus on real-time detection, autonomous response, and seamless integration ensures businesses can stay ahead of ransomware, phishing, and advanced attacks.
These USA-based companies empower organizations with scalable, enterprise-grade solutions, addressing the complexities of distributed networks and remote workforces. By combining cutting-edge technologies with tailored services, they are shaping the future of endpoint security, fostering resilience and trust in an increasingly connected digital landscape.
